Dr. Holmes now in the Cardiac Biomechanics Group at the University of Columbia has kindly provided the infarct remodelling data from his PhD thesis in collaboration with Dr. James Covell and Dr. Andrew McCulloch.

Contact details:
Dr. Jeffrey W. Holmes (jh553@columbia.edu )
Dr. James Covell, UC San Diego (Medicine) ( jcovell@ucsd.edu )
Dr. Andrew McCulloch, UC San Diego (Bioengineering) (amcculloch@ucsd.edu )

A Passive Study :

Infarcts were created in pigs and left to heal for 3 weeks.

At three weeks, the chest was opened and three columns of 3-4 beads were put into the infarct (lateral wall, between papillary muscles) and another 3 columns into the noninfarcted anterior wall.

The heart was then arrested, removed, and passively inflated while videotaping both beadsets. The coordinates of the beads at a series of cavity pressures during these passive experiments were digitised.

The hearts were sliced perpendicular to the long axis of the LV, scanned in, and digitized. The slices were about 5 mm thick

This data set contains the passive strains, the digitized geometric data (endo contour, epi contour, and infarct outline), and good histology with collagen fiber angle data at multiple depths across the infarcts.