\ Publications
- Sands, G.B., Gerneke, D.A., Hooks, D.A., Green, C.R., Smaill, B.H., LeGrice, I.J. Automated imaging of extended tissue volumes using confocal microscopy, Microscopy Research and Technique, 67(5), 227-239, 2005.   [PubMed]
- Trew, M., Smaill, B., Pullan, A. What of Cleavage Planes? The state-of-the-art in microstructure modeling of cardiac activation. International Journal of Bioelectromagnetism, 7(1), 299-302, 2005.
- Trew, M.L., Caldwell, B.J., Sands, G.B., Hooks, D.A., Tai, D.C.S., Austin, T.M., LeGrice, I.J., Pullan, A.J., Smaill, B.H., Cardiac electrophysiology and tissue structure: bridging the scale gap with a joint measurement and modelling paradigm, Experimental Physiology, 91(2), 355-370, 2006.
- Hooks, D., Trew, M., Smaill, B., Pullan, A. evidence that intramural virtual electrodes facilitate successful defibrillation. model based analysis of experimental evidence. Journal of Cardiovascular Electrophysiology, 17(3), 305-311, 2006.   [PubMed]
- Schmid, H., Nash, M.P., Young, A.A., Rohrle, O. and Hunter, P.J. A computationally efficient optimization kernel for material parameter estimation procedures, Journal of Biomechanical Engineering, (In review) 2006.
- Schmid, H., Nash, M.P., Young, A.A. and Hunter, P.J. Myocardial material parameter estimation - A comparative study for simple shear. Journal of Biomechanical Engineering, (In Press), 2006.
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- Trew, M., Smaill, B.H., Bullivant, D.P., Hunter, P.J., and Pullan, A.J. A generalised finite difference method for modeling cardiac electrical activation on arbitrary, irregular computational meshes. Mathematical Biosciences. 198(2), 169-189, 2005.
- Trew, M., LeGrice, I., Smaill, B., Pullan, A. A finite volume method for modeling discontinuous electrical activation in cardiac tissue. Annals of Biomedical Engineering, 33(5), 590-602, 2005.
- Trew, M., Sands, G.B., Shock-induced transmembrane potential fields in a model of cardiac microstructure, Journal of Cardiovascular Electrophysiology, 16(9), 1024, 2005.
- Pullan, A.J., Sands, G.B., Trew, M., Hooks, D.A., LeGrice, I.J., Smaill, B.H., Electrical activity on tissue-specific ventricular models. Journal of Electrocardiology 38(4, Supplement 1),143, 2005.
- Austin, T., Trew, M., Pullan, A. Solving the cardiac bidomain equations for discontinuous conductivities. IEEE Transactions on Biomedical Engineering, 53(7), 1265-1272, 2006.
- Remme, E.W., Augenstein, K.F., Young, A.A. and Hunter, P.J. Parameter distribution models for estimation of population based left ventricular deformation using sparse fiducial markers. IEEE Transactions on Medical Imaging. 24(3):381-388, 2005.
- Cheng, L.K., Sands, G.B., French, R.A., Withy, S.J., Wong, S.P., Legget, M., Smith, W.M., Pullan, A.J., Rapid construction of a patient specific torso model from 3d ultrasound for noninvasive imaging of cardiac electrophysiology. Medical and Biological Engineering and Computing, 43(3), 325-330, 2005.
- Austin, T., Hooks, D., Hunter, P., Nickerson, D., Pullan, A., Sands, G., Smaill, B., Trew, M. Modelling cardiac electrical activity at the cell and tissue levels. Annals of NY Academy of Sciences, 1080, in press, September, 2006.
- Hunter, P.J. and Nielsen, P.M.F. A strategy for integrative computational physiology. Physiology. 20:316-325, 2005.
- Hunter, P.J., Burrowes, K., Fernandez, J., Nielsen, P, Smith, N. and Tawhai, M. The IUPS Physiome Project: Progress and plans. Chapter 17 in ‘Computational Systems Biology’, Eds A. Kriete and R. Eils. Elsevier, pp 383-394, 2005.
- Hunter, P.J. Modeling living systems: the IUPS/EMBS Physiome Project. Proceedings of the IEEE. 94:678-691, 2006.
- Nickerson, D.P. and Hunter, P.J. The Noble cardiac ventricular electrophysiology models in CellML. Prog. Biophys. Molec. Biol. 90:346-359, 2006.
- Nickerson, D., Nash, M.P., Nielsen, P.M.F., Smith, N.P. and Hunter, P.J. Computational multiscale modeling in the physiome project: modeling cardiac electromechanics. IBM Research J. In Press, 2006
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- Nash, M.P., Mourad, A., Clayton, R.H., Sutton, P.M., Bradley, C.P., Haywood, M., Paterson, D.J., Taggart, P. Evidence for multiple mechanisms in human ventricular fibrillation. Circulation Aug 8;114(6):536-42, 2006. [see commentary by Ideker, R.E., Rogers, J.M. Human ventricular fibrillation: wandering wavelets mother rotors or both? Circulation.114(6):530-2, 2006.]
- Nash M.P., Bradley C.P., Sutton P.M., Clayton R.H., Kallis P., Hayward M.P., Paterson D.J. and Taggart P. Whole heart APD restitution properties in cardiac patients: a combined clinical and modelling study. Exp Physiol Feb 1, 2006.
- Ying, C., Nash, M.P., Wing, X., Wang, Y., Paterson, D.J. and Wang, J. Multi-fractal ECG mapping of ventricular epicardium during regional ischaemia in the pig. IEEE transaction on Biomedical Eng. (In press), 2006.
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- Swietach P, and Vaughan-Jones R.D. Spatial regulation of intracellular pH in the ventricular myocyte. Annals.N.Y Acad.Sci. 1047, 271-82, 2005.
- Swietach P, Spitzer KW, Vaughan-Jones RD. Experimental generation and computational modeling of intracellular pH gradients in cardiac myocytes. Biophysical Journal. 88(4), 3018-3037, 2005.
- Nickerson, D., Smith, N.P. and Hunter, P.J. New developments in a strongly coupled cardiac electromechanical model. Europace, 7, S118-S127, 2005.
- Vaughan-Jones RD, Spitzer KW, Swietach P. Spatial aspects of intracellular pH regulation in heart muscle. Prog.Biophys.Mol.Biol. Jan-Apr;90(1-3):207-24, 2006.
- Niederer SA, Hunter PJ, Smith NP. A quantitative analysis of cardiac myocyte relaxation: a simulation study. Biophys J. 1;90(5):1697-722, 2006.
- Lee J., Smaill B.H., Smith N.P. Hodgkin-Huxley ion channel characterization: An improved method of voltage clamp experiment interpretation. Journal of Theoretical Biology, 2006
- Crampin E.J., Smith N.P. A dynamic model of excitation-contraction coupling during acidosis in cardiac ventricular myocytes. Biophysical J. 90:3074-3090, 2006.
- Crampin E., Smith N.P., Langham A., Clayton R. and Orchard C. Acidosis in models of cardiac ventricular myocytes. Phil. Trans. R. Soc. Lond. 364 1171-1186, 2006.
- Vaughan-Jones RD, Villafuerte FC, Swietach P, Yamamoto T, Rossini A, Spitzer KW. pH-regulated Na+ influx into the mammalian ventricular myocyte: the relative role of Na+ -H+ exchange and Na+ -HCO3 - co-transport. Journal of Cardiovascular Electrophysiology. May;17 Suppl 1:S134-S140, 2006.
- Vaughan-Jones RD, Spitzer KW, Swietach P. Spatial aspects of intracellular pH regulation in heart muscle. Prog.Biophys.Mol.Biol. Jan-Apr;90(1-3):207-24, 2006.
- Ch'en F F-T, Villafuerte FC, Swietach P, Cobden PM, Vaughan-Jones RD. S0859, an N-cyanosulphonamide inhibitor of sodium-bicarbonate co-transport in the heart. British Journal of Pharmacology. In Press, 2007.
- Niederer SA, Swietach P, Wilson DA, Smith NP, Vaughan-Jones RD. Measuring and modeling chloride-hydroxyl exchange in the guinea-pig ventricular myocyte. Biophysical Journal. In Press Epub ahead of print published on November 30, 2007 as doi:10.1529 biophysj.107.118885
- Stewart AK, Kurschat CE, Vaughan-Jones RD, Shmukler BE & Alper SL. Acute regulation of mouse AE2 anion exchanger requires isoform-specific amino acid residues from most of the transmembrane domain. J. Physiol. Oct 1;584(Pt 1):59-73, 2007.
- Swietach P, Vaughan-Jones RD, Harris AL. Regulation of tumor pH and the role of carbonic anhydrase 9. Cancer Metastasis Reviews. Jun;26(2):299-310, 2007.
- Swietach P, Rossini A, Spitzer KW, Vaughan-Jones RD. H+ Ion Activation and Inactivation of the Ventricular Gap Junction. A Basis for Spatial Regulation of Intracellular pH. Circ Res. 100:1045-1054, 2007.
- Swietach P, Spitzer KW, Vaughan-Jones RD. pH-dependence of extrinsic and intrinsic H+-ion mobility in the rat ventricular myocyte, investigated using flash photolysis of a caged-H+ compound. Biophys J. Jan 15;92(2):641-53, 2007.
- Stewart AK, Kurschat CE, Burns D, Banger N, Vaughan-Jones RD, Alper SL. Transmembrane domain histidines contribute to regulation of AE2-mediated anion exchange by pH. Am J Physiol Cell Physiol. Feb;292(2):C909-18, 2007.
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- Danson, E.J.F., Zhang, Y.H., Sears, C.E., Edwards, A.R., Casadei, B., & Paterson, D.J. Disruption of inhibitory G-proteins mediates a reduction in atrial beta-adrenergic signaling by enhancing eNOS expression. Cardiovas Res. 2005 Sep 1;67(4):613-23 [See commentary by Muller F.U. (2006). Increased eNOS expression as a compensatory mechanism reducing beta-adrenergic responsiveness? Cardiovasc Res. 2005 Sep 1;67(4):575-7.]
- Heaton, D.A., Golding, S., Bradley, C.P., Dawson, T.A., Cai, S., Channon, K.M. & Paterson, D.J. Targeted nNOS gene transfer into the cardiac vagus rapidly increases parasympathetic function in the pig. J. Mol. Cell. Cardiol. Jul;39(1):159-64, 2005.
- Wang, L., Li, D., Plested, C.P., Dawson, T.D., Teschemacher, A. and Paterson, D.J. Noradrenrgic neuron-specific overexpression of nNOS in cardiac sympathetic nerves decreases neurotransmission. J Mol Cell Cardiol. Aug;41(2):364-70, 2006. [highlighted front page article]
- Heaton, D.A., Lei, M., Li, D., Golding, S., Dawson, T.A., Mohan, R.M., and Paterson, D.J. Remodelling of cardiac pacemaker ICaL and its beta-adrenergic responsiveness in hypertension following nNOS gene transfer. Hypertension 48: 443-452, 2006.
- Heaton, D.A., Lei, M., Li, D., Golding, S., Dawson, T.A., Mohan, R.M., and Paterson, D.J. Remodelling of Cardiac Pacemaker I_CaL and Beta-adrenergic Responsiveness in Hypertension following nNOS Gene Transfer. Hypertension 48:443-452, 2006.
- Danson E.J. and Paterson D.J. Reactive oxygen species and autonomic regulation of cardiac excitability. J Cardiovasc Electrophysiol. vol 17 p 1-9 Suppl 1. April., 2006.
- Herring, N., and Paterson, D.J. Common NOS1AP Variants Are Associated With a Prolonged QTc Interval in the Rotterdam Study Circulation 116 e564, 2007. [Letter to Editor]. Response to letter Aarnoudse, A-J.L.H.J., Straus, S.M.J.M., Hofman, A., Uitterlinden, A.G., Witteman, J.C.M., and Stricker, B.H.C. Circulation 116 e565, 2007.
- Wang, L., Henrich, M., Buckler, K., McMenamin, M., Mee, C.J., Sattelle, D.B., and Paterson, D.J. Neuronal nitric oxide synthase gene transfer decreases [Ca2+]i in cardiac sympathetic neurons J Mol Cell Cardiol. 43(6):717-25, 2007.
- Li, D., Wang, L., Chee-Wan, L., Dawson, T.A., and Paterson, D.J. Noradrenergic Cell Specific Gene Transfer With Neuronal Nitric Oxide Synthase Reduces Cardiac Sympathetic Neurotransmission in Hypertensive Rats. Hypertension 50(1):69-74, 2007.
- Heaton, D.A., Li, D., Almond, S.C., Dawson, T.A., Wang, L., Channon, K.M., and Paterson, D.J. (2007) Gene Transfer of nNOS into Intracardiac Ganglia Reverses Vagal Impairment in Hypertensive Rats Hypertension 49:380-388, 2007.
- Paterson, D.J. Celebrating 100 years of publishing discovery in physiology 1908-2008. Exp. Physiol. 93(1):1-15, 2008.
- Herring, N., Lokale, M.N., Danson, E.J., Heaton, D.A., and Paterson, D.J. Neuropeptide Y reduces acetylcholine release and vagal bradycardia via a Y2 receptor-mediated, protein kinase C-dependent pathway. J Mol Cell Cardiol. 2007 Oct 11 Epub ahead of print, 2008.
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- Bemporad, D., Sands, Z.A., Wee, C.L., Grottesi, A. and Sansom, M.S.P. VSTx1, a modifier of Kv channel gating, localizes to the interfacial region of lipid bilayers. Biochem. 45:11844-11855, 2006.
- Wee, C.L., Bemporad, D., Sands, Z.A., Gavaghan, D. and Sansom, M.S.P. SGTx1, a Kv channel gating-modifier toxin, binds to the interfacial region of lipid bilayers. Biophys. J. (submitted), 2006
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